Evaluation of Viral Genome Copies Within Viral Factories on Different DNA Viruses

Viral Oncogenesis: DNA Viruses

Viral diseases: DNA viruses

The disease is caused by members of the gammaherpesviruses group. Alcelaphine herpesvirus-1 (AHV-1), carried asymptomatically by the wildebeest (Connochaetes taurinus) in Africa, has been diagnosed in disease outbreaks in zoos in North America. Ovine herpesvirus-2 (OHV-2) is carried asymptomatically by sheep (117). A third, as yet unnamed virus, has been detected in an outbreak of MCF in white-...

Architecture of viral replication factories

Compartmentalization of intracellular membrane is a marked characteristic during the pathogenesis of many viruses, which provides a microenvironment for virus to evade the host RNA interference defense response on one hand, and confines various host factors as well as metabolites in a stable space so that they can act in concert to complete virus replication cycle [1]. Recently, advanced imagin...

Viruses and viral proteins

For more than 30 years X-ray crystallography has been by far the most powerful approach for determining the structures of viruses and viral proteins at atomic resolution. The information provided by these structures, which covers many important aspects of the viral life cycle such as cell-receptor recognition, viral entry, nucleic acid transfer and genome replication, has extensively enriched o...

Sequence-independent targeting of transmembrane proteins synthesized within vaccinia virus factories to nascent viral membranes.

The primary membrane of vaccinia virus, as well as those of other poxviruses, forms within a discrete cytoplasmic factory region. We recently determined the existence of an operative pathway from the endoplasmic reticulum within the virus factory to nascent viral membranes and demonstrated that a viral protein could be diverted from this pathway to Golgi membranes by the addition of COPII-bindi...